过敏菌商城| ① 纳入16名重症监护病房（ICU）的患者进行益生菌饮料干预，另纳入16名匹配患者为对照；
② 试验组病人通过饲管每天服用两瓶含干酪乳杆菌Paracasei CNCM I-1518的饮料，与抗生素治疗间隔2小时以上； ③ 试验组中无严重不良事件，抗生素相关腹泻（AAD）发生率12.5%（对照组为31.3%），1名患者发生艰难梭菌感染（CDI）（对照组中3名）； ④ 饲管喂食该益生菌饮料在ICU病人中安全性良好，或能用于预防ICU中的AAD和CDI。
Nutrients [IF:3.55]
Feasibility of a Lactobacillus casei Drink in the Intensive Care Unit for Prevention of Antibiotic Associated Diarrhea and Clostridium difficile DOI: 10.3390/nu10050539. Abstract: Background: Over 70% of patients are prescribed antibiotics during their intensive care (ICU) admission. The gut microbiome is dramatically altered early in an ICU stay, increasing the risk for antibiotic associated diarrhea (AAD) and Clostridium difficile infections (CDI). Evidence suggests that some probiotics are effective in the primary prevention of AAD and CDI. Aim: To demonstrate safety and feasibility of a probiotic drink in ICU patients. Methods: ICU patients initiated on antibiotics were recruited, and matched with contemporary controls. Study patients received two bottles daily of a drink containing 10 billion Lactobacillus casei which was bolused via feeding tube. Tolerance to probiotics and enteral nutrition, development of adverse events, and incidence of AAD was recorded. CDI rates were followed for 30 days post antibiotic treatment. Results: Thirty-two patients participated in the trial. There were no serious adverse events in the probiotic group, compared to three in the control group. AAD was documented in 12.5% of the probiotic group and 31.3% in the control group. One patient in the probiotic group developed CDI compared to three in the control group. Discussion: A probiotic containing drink can safely be delivered via feeding tube and should be considered as a preventative measure for AAD and CDI in ICU. First Authors: Cathy Alberda Correspondence: Cathy Alberda All Authors: Cathy Alberda, Sam Marcushamer, Tayne Hewer, Nicole Journault and Demetrios Kutsogiannis 4/26/18Article
免责声明：本文仅代表作者个人观点，与中国益生菌网无关。其原创性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不作任何保证或承诺，请读者仅作参考，并请自行核实相关内容。
版权声明
本网所有转载文章、链接及图片系出于传递更多信息之目的，且明确注明来源和作者，不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
|
益生菌能否减少ICU的抗生素相关腹泻和CDI？
未经允许不得转载：过敏菌商城 » 益生菌能否减少ICU的抗生素相关腹泻和CDI？
